Antagonists, or simply enemies, are the main villains of the Manhunt series. The antagonist is usually a person that has betrayed or hurt the protagonist on a personal and social level, and spends the game moving against the protagonist in multiple ways.
All antagonists in Manhunt series won't or sometimes appear in the whole game, mostly as the protagonists' "guide". Antagonists usually has a henchman that fights against the protagonist.
They usually appear as an ally or a friend in the early levels in a game and eventually betray them. The protagonist sometimes may hunt down and kills the antagonist and sometimes may not make it, and instead, antagonist kills the protagonist.
The only antagonist that is also a protagonist is Leo. Danny is also the antagonist in the alternate ending of Manhunt 2, in the bonus mission Release Therapy while being the main protagonist in the whole storyline.
Current list of antagonists in the Manhunt series 
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ManhuntEdit
 Lionel Starkweather | Lionel Starkweather also known as the Director is the main antagonist of Manhunt. | |
| Scene appearances: Deliverance (killed) | ||
 Piggsy | Piggsy is a deranged, cannibalistic mass murderer who wears a skinned pig's head over his face and slaughters his victims with a chainsaw. | |
| Scene appearances: Grounds for Assault, Trained to Kill, Deliverance (killed) | ||
 Cerberus Leader | Cerberus Leader, the head of Starkweather's personal security unit. | |
| Scene appearances: Road to Ruin, Trained to Kill, Key Personnel (killed) | ||
 Ramirez | Ramirez, hulking one-eyed Afro-Latino ex-soldier, and the leader of The Wardogs. | |
| Scene appearances: White Trash, Grounds for Assault, View of Innocence, Divided They Fall (killed) | ||
Manhunt 2Edit
 Leo Kasper | Leo Kasper is deuteragonist later revealed to be the main antagonist of Manhunt 2. He is also protagonist of flashback missions. | |
| Scene appearances: Personality Clash (killed), Release Therapy (survives) | ||
 Dr. Pickman | Dr. Pickman, founder of The Project. He is a heartless and cruel person, caring little about the suffering that his experiments cause on his test subjects. He created the "Pickman Bridge", the final product of the Project, which would implant a separate personality with an expertise in killing into an unknowing subject. | |
| Scene appearances: Awakening, Ghosts (voice only), Origins (killed), Domestic Disturbance, Personality Clash (as a memory of Daniel) | ||
 Michael Grant | Michael Grant, the best friend and co-worker of Daniel Lamb. Just like Danny, Michael worked for The Project and was a high ranking scientist. | |
| Scene appearances: Best Friends (killed), Origins (flashback), Personality Clash (Daniel Lamb's memory) | ||
